This study compared efficacy and safety of basic triple therapy according to treatment period. This study evaluated Effect of CYP2C19 genetic polymorphisms on the efficacy
This study compared efficacy and safety of basic triple therapy including Noltec(Ilaprazole) 10mg, Clapaxine(Clarithromycin) 500mg and Pamoxin Cap(Amoxicillin) 1000mg BID on the first line eradication treatment of H.pylori according to treatment period. Participants are defined as persons who have endoscopically confirmed on gastric or duodenal ulcer(including scar stage) and gastritis confirmed to be H.pylori positive patients in the UBT test. For 7 days or 10 days Participants treated as basic triple therapy including Noltec(Ilaprazole) 10mg, Clapaxine(Clarithromycin) 500mg and Pamoxin Cap(Amoxicillin) 1000mg BID. After treatment, The healing rate was evaluated in the UBT test at 49±5days from the first day dosing. The investigators would point out the impact of CYP2C19 genotypes on Clarythromycin-based first-line and rescue therapies.
Study Type
OBSERVATIONAL
Enrollment
320
7 days treatment or 10 days treatment
The Catholic Univ. of Korea Daejeon St.Mary Hospital
Daejeon, South Korea
RECRUITINGThe Chunngnam Univ. General Hospital
Daejeon, South Korea
NOT_YET_RECRUITINGThe Eulji Univ. General Hospital
Daejeon, South Korea
NOT_YET_RECRUITINGThe eradication rate of H.pylori at Day 49±5(or Day 52±5) as assessed by UBT test or Biopsy
The eradication rate of H.pylori after 7 days(or 10 days) treatment is defined as those participants who have endoscopically confirmed on gastric or duodenal ulcer(including scar stage) and gastritis confirmed to be H.pylori positive patients in the biopsy or UBT test. The treatment : Noltec(Ilaprazole) 10mg+Pamoxine Cap(Amoxicillin) 1000mg+Clafaxine(Clarithromycin) 500mg was administered twice a day for 7days(or 10days)
Time frame: Day 49±5(or Day 52±5)
The safety of Noltec(Ilaprazole) 10mg BID treatment at Day 49±5(or Day 52±5). Record the number of patients with adverse Events.
Record the number of patients with adverse Events. Also Record the symptoms, date, duration, and intensity of Adverse events such.
Time frame: Day 49±5(or Day 52±5)
The eradication rate of H.pylori according to CYP polymorphism of patients.
The eradication rate of H.pylori is analyzed accroding to CYP polymorphism: CYP2C19 homo EM, hetero EM, PM
Time frame: Day 49±5(or Day 52±5)
The eradication rate of H.pylori according to stage of disease of patients.
The eradication rate of H.pylori is analyzed accroding to stage of disease: active stage, healing stage, scar stage, gastritis.
Time frame: Day 49±5(or Day 52±5)
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The Konyang Univ. General Hospital
Daejeon, South Korea
NOT_YET_RECRUITING