Secondhand Smoking in Asthmatic Children

AHEPA University Hospital90 enrolled

Overview

This study will investigate the interaction between GSTP1 / TNFa polymorphisms and passive smoking in children with asthma/wheezing. Contemporary second hand-smoke exposure will be confirmed by laboratory testing.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Asthma in Children Wheezing

Interventions

Lung functionDIAGNOSTIC_TEST

Spirometry test

White blood cell DNA extractionDIAGNOSTIC_TEST

GSTP1 and TNFa polymorphisms with PCR

Urinary testingDIAGNOSTIC_TEST

Urinary nicotine and cotinine detection

Eligibility

Sex: ALLMin age: 12 MonthsMax age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Subjects 1-18 years old with doctor diagnosed asthma/wheezing Exclusion Criteria: * Premature birth (\< 36 gestation weeks) * Asthma-like symptoms due to other conditions (infectious, congenital, mechanical)

Outcomes

Primary Outcomes

GSTP1 and TNFa variants in children with asthma

Time frame: 0 days

Data from ClinicalTrials.gov

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