Studies demonstrate that exercise increases the maximal oxygen uptake, peak oxygen consumption, reduce effort-induced lactic acid production, and increase skeletal muscle oxidative capacity, as well as psychological aspects such as increased self-esteem and improvement of the quality of life. In the literature there is only one study involving rehabilitation in hospitalized pediatric patients with cystic fibrosis. Thus, more information on in-hospital rehabilitation is required in adult cystic fibrosis patients. The present study aims to evaluate the effects of an early rehabilitation program, based on aerobic training and muscle strength training, in adolescent and adult patients with cystic fibrosis hospitalized at Hospital de Clinicas de Porto Alegre for exacerbation of lung disease.
After completing the study inclusion criteria, the individual will be invited to participate and will receive the consent form for signature. The patient will be submitted to the following evaluations: quality of life questionnaire for cystic fibrosis, spirometry, Shwachman-Kulczycki score, modified dyspnea questionnaire (Modified Medical Research Council), maximum repetition test, six minute walk test and blood sample for the determination of inflammatory markers. These evaluations should be performed within the first 48 hours of hospitalization, and will be repeated on the last day of hospitalization. In the period up to 48 hours after hospital admission, patients will be randomized to either the intervention group or the control group.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
34
Patients randomized to the intervention group, in addition to routine physical therapy follow-up, will receive an early rehabilitation program, which will begin within the first 48 hours after admission. The patient will perform physical training (aerobic and anaerobic) 5 times a week during the hospitalization period, with sessions about an hour. The professional who supervises the training will be blinded to the results of the measurements.
Patients randomized to the control group will continue to receive the physiotherapeutic follow-up performed by the physiotherapist of the Program for Adults with CF during the hospitalization period. Supervision includes respiratory physiotherapy involving inhalation therapy and techniques for removal of secretions
Paulo de Tarso Dalcin
Porto Alegre, Rio Grande do Sul, Brazil
Distance walked during the six minute walk test
The six-minute walk test will be performed at hospital discharge.
Time frame: up to 14 days
Forced expiratory volume in the first second
The spirometry will be performed at hospital discharge.
Time frame: up to 14 days
Cystic fibrosis quality of life questionary
Cystic fibrosis quality of life questionary will be performed at hospital discharge.
Time frame: up to 14 days
C-reative protein
C-reative protein will be performed at hospital discharge.
Time frame: up to 14 days
Interleukin-6
Interleukin-6 will be performed at hospital discharge.
Time frame: up to 14 days
Interleukin-8
Interleukin-8 will be performed at hospital discharge.
Time frame: up to 14 days
Tumor necrosis factor
Tumor necrosis factor will be performed at hospital discharge.
Time frame: up to 14 days
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