This study uses a meal-challenge protocol to assess if patients with anorexia nervosa show a differential metabolism in response to food in comparison to healthy controls. This study determines how heritable and biochemical factors influence food metabolism in anorexia nervosa in order to develop more effective treatment strategies.
Anorexia nervosa is a brain-based disorder that often leads to serious health consequences including death. The EPHX2 gene has been identified as a susceptibility gene for anorexia nervosa. This study utilizes a multi-omics biomarker system approach to investigate how genetic factors interact with dietary factors to influence food aversion, psychopathology, and clinical outcome in patients with anorexia nervosa.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
300
A meat-based breakfast sandwich
UC San Diego Altman Clinical and Translational Research Institute
La Jolla, California, United States
RECRUITINGProgram for Eating Disorders, Toronto General Hospital
Toronto, Ontario, Canada
RECRUITINGChange of metabolism biomarker
Percentage change of metabolism marker
Time frame: 2 hours
Food aversion/anxiety
Percentage change of food aversion/anxiety score
Time frame: 2 hours
Weight
Change in body weight, kg
Time frame: 6 and 12 months
Psychopathology
Percentage change in eating disorder psychopathology score
Time frame: 6 and 12 months
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