Tibial Fracture - Platelet-rich Plasma and Bone Marrow Concentrate

Inclusion Criteria: * Aged 18-65, skeletally mature adults. * Acute unilateral closed tibia diaphyseal fractures as the primary injury. * Definitive fracture fixation with reamed intramedullary nailing (statically locked) or fine wire ring external fixator to be performed within 14 days from the date of injury. * Willing and able (in the opinion of the study team) to provide informed consent and participate in all study activities. Exclusion Criteria: * Open/compound tibial fracture. * Fracture Type 42-C2 according to Muller AO classification. * Multi-segmental nature of this fracture (more than one fracture site within tibia for intervention.) * Polytrauma (defined as injury severity score of 17 or more.) * Prior or concomitant illnesses that may affect healing. * Exposure to drugs that can affect the bone metabolic state within the past three months. * Receiving chemotherapy, radiation treatment or immunosuppression drugs. * Currently enrolled in any other study which may impact on the results of the present study. * If female: pregnancy, breast-feeding, not currently using and not willing to use an effective form of contraception for 12 months post-surgery.