Effect of Probiotic on Constipation

China Agricultural University62 enrolled

Overview

Constipation is a prevalent intestinal disorder. Lactobacillus casei strain Shirota (LcS) shows potential effect on alleviating constipation. This study evaluated the impact of fermented milk containing LcS on stool consistency and frequency. The stool short chain fatty acid and gut microbiota were also assessed.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Constipation

Interventions

Lactobacillus casei strain ShirotaDIETARY_SUPPLEMENT

a bottle of 100 mililiter probiotic dairy beverage containing 10\^8 CFU Lactobacillus casei strain Shirota every day after lunch.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: * meet ROME Ⅲ criteria for functional constipation * normal body mass index between 18.5 and 29.9 Exclusion Criteria: * had a serious disease; * used systemic antibiotics or antimycotics medication and antidiarrheal or laxative medication in the 30 days prior to the study; * allergic to milk protein; * constipated because of organic or neurological lesions; * participated in any other studies within 2 months prior to this study.

Outcomes

Primary Outcomes

change of stool consistency

Time frame: change from baseline stool consistency at four-week intervention

change of defecation frequency

Time frame: change from baseline defecation frequency at four-week intervention

change of constipation-related symptom scores

Time frame: change from baseline constipation-related symptom scores at four-week intervention

Secondary Outcomes

Changes in stool short chain fatty acid content

Time frame: change from baseline stool short chain fatty acid content at four-week intervention

Changes in gut microbiota

Time frame: change from baseline gut microbiota at four-week intervention

Data from ClinicalTrials.gov

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