Vitamin D deficient pregnant ladies were selected and randomized into 2 groups for routine daily dose of multivitamin (400IU vitamin D3) versus maximum safest treatment daily dose (4000IU vitamin D3). Participants were assessed and compared for number of pre-eclampsia cases.
Vitamin D3 has key role in decidualization and implantation of placenta.Vitamin D deficiency is thought to have positive association with pre-eclampsia.Vitamin D deficiency is highly prevalent in some parts of the world and it is not universally screened antenatally. Pre-eclampsia is a known multifactorial pregnancy disorder with significant maternal and perinatal morbidity and mortality. Vitamin D3 has a down-regulating effect on inflammatory pathways and reducing endothelial cell damage. Investigators want to assess in vitamin D deficient group whether treatment reduces the risk of pre-eclampsia.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
179
Antenatal multivitamin
4000 IU Vitamin D3 (cholecalciferol) daily = 40 drops daily
Number of Participants With Pre-eclampsia in Both Arms
Occurrence of pre-eclampsia or not in all patients irrespective of Vitamin D dose.
Time frame: From 20 weeks of pregnancy till event of pre-eclampsia seen, whichever came first, assessed up to 32 weeks.
Change in Vitamin D Level
Level of Improvement in Vitamin D status in both arms
Time frame: At 36th week of pregnancy
Number of Patients With Intrauterine Growth Retardation
Patients having fetus with retardation of growth in both arms.
Time frame: At delivery
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