Inspiratory Muscle Training in Pulmonary Hypertension

Federal University of São Paulo32 enrolled

Overview

Inspiratory muscle training for 8 weeks in patients with pulmonary hypertension.

32 patients with PH will perform: 1) pulmonary function tests; 2) measurement of maximal inspiratory pressure (MIP) and endurance; 3) six-minute walk test and 5) incremental and constant load cardiopulmonary exercise test (\~ 75% of maximal work-rate) and step test. Inspiratory muscle training will consist of twice daily sessions of 30 breaths (\~ 50% PiMAX, 4-5 minutes per session) for 8 weeks. The SHAM group will perform sessions of 30 breaths with no inspiratory load.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Chronic Thromboembolic Pulmonary Hypertension Inspiratory Muscle Training Inspiratory Muscle Weakness Pulmonary Arterial Hypertension

Interventions

inspiratory muscle trainingOTHER

inspiratory muscle training with 50% of MIP

Placebo "training"OTHER

placebo training with PowerBreathe (without inspiratory load)

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * CTEPH confirmed by RHC and imaging * NYHA FC II-IV Exclusion Criteria: * Limitation to cycling * Recent syncope or clinical deterioration

Locations (1)

SEFICE - Setor de Função Pulmonar e Fisiologia Clínica do Exercício

São Paulo, São Paul, Brazil

Outcomes

Primary Outcomes

exercise capacity¨- cardiopulmonary exercise testing

TLim (seconds)

Time frame: week 8

exercise capacity - 6-min walk test

distance (m)

Time frame: week 8

Secondary Outcomes

ventilatory responses

VE/VCO2

Time frame: Week 8

Data from ClinicalTrials.gov

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