Does Single Dose Imipramine Affect the Opening Pressure of the Urethral and Anal Sphincter?

Inclusion Criteria: * Signed consent form. * Healthy. * Female. * Non-smoker. * Age 18 to 55, both inclusive. * Normal weight: BMI 19.5 to 30.0 kg/m2. Weight minimum 50 kg. * No breastfeeding. * No pregnancy during the study. * No other clinical trials during the study. Exclusion Criteria: * Known allergy to imipramine or any of the other known constituents. * Medical history with significant cardiovascular, gastrointestinal, endocrinologic, hematologic, immunologic, metabolic, genitourologic, dermatologic, psychiatric, neurologic or dermatologic disease, lung disease, kidney disease, malignant disease or other significant diseases as assessed by the investigator. * Medical history of urinary incontinence. * Infectious disease 1 week prior to study day 1 or study day 2. * Clinically significant findings during the physical examination. * Pregnancy. * Heart rate \< 40 or \> 100 beats per minute. Mean systolic blood pressure \> 140 mmHg or mean diastolic blood pressure \> 90 mmHg (mean of the measures on the screening day). * Prescription, over the counter or herbal medication two weeks prior to study day 1 or study day 2. Excluding paracetamol and excluding oral contraceptives. * Smoking 3 months prior to study day 1 or study day 2. * Alcohol abuse, meaning \> 14 units (12 g alcohol) per week within three weeks prior to study day 1 or study day 2. * Drug abuse 3 months prior to study day 1 or study day 2. * Any condition as assessed by the investigator.