Healthy Nordic Foods to Prevent Cardiometabolic Risk in Obese Subjects

Lund University80 enrolled

Overview

This project will examine whether long-term consumption of healthy Nordic foods can maintain a healthy weight also after weight loss, and decrease abdominal fat accumulation and cardiometabolic risk. The study will be performed with the aim to achieve a substantial body weight loss in the first phase by prescribing a standardized low caloric dietary formula. The follow-up phase will be a body weight-maintenance period and the subjects will be randomised to a healthy Nordic diet group and a control diet group. During the study body weight will be monitored and other measurements will include insulin sensitivity, blood lipids and inflammation markers.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Enrollment

Conditions

Obesity Cardiovascular Risk Factor Diet Modification

Interventions

Eligibility

Sex: ALLMin age: 25 YearsMax age: 67 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * age 25-67 years, BMI 30-40 kg/m2, waist circumference men \>102cm and women \> 88cm or sagittal abdominal diameter men \>22cm and women \>20cm, stable body weight Exclusion Criteria: * glucose \>7.0 mmol/l, B-Hb1aC \>48 mmol/L, triglycerides \>4 mmol/l, total cholesterol \>8 mmol/l, bloodpressure \>160/100 mmHg, chronic disease, gastro-intestinal disease, hyper-/hypothyroidism, alcohol abuse, cancer, gastric bypass operation, gluten allergy, lactose intolerance, pregnancy

Outcomes

Primary Outcomes

Change in sagittal abdominal diameter

Time frame: Change from baseline to month 6, 12, 18, 24

Change in body weight

Time frame: Change from baseline to month 6, 12, 18, 24