Effects of Probiotic on Modulation of the Intestinal Microbiota in Constipated Patients

Inclusion Criteria: * Agree to adhere to the procedures and requirements of the study and attend the institute on the day (s) and time (s) determined for the evaluations; * Being able to consent study participation * Have one or more complaints of change in bowel habits in the last 3 months with onset of symptoms at least 6 months before diagnosis, as described below: * Evacuation effort for at least 25% of defecations * Lumpy stools, on sausage-shaped or hardened in at least 25% of stools, according to the Bristol scale. number 1, 2 or 3; * Incomplete evacuation count in at least 25% of defecations; * Feeling of anorectal obstruction / blockage of feces in at least 25% of defecations; * Manufactured manuals to facilitate at least 25% of stools (for example, evacuation with digital help, pelvic floor support) Exclusion Criteria: * Pregnancy or breast-feeding; * Known intolerance or allergy to any of the study products; * Previous history of gastrointestinal surgery; * Patients with celiac disease or inflammatory bowel disease; * Patients with psychiatric, cardiologic, respiratory, renal and hepatic disease; * No acceptance of study admission by the participant; Diagnosis of Clostridium difficile diarrhea in the last 3 months; * Patients with known immunosuppressive disease; * Any other gastrointestinal pathology; * Prior use of antibiotics in less than 30 days; * Frequent use of laxatives or other medication that alters bowel motility (one week without Use before inclusion) * Regular treatment with probiotics / symbiotic, including regular use of yogurt with probiotics (One week before use before inclusion) * Regular use of antidepressant, opioid analgesic, antispasmodic or anticholinergic agents