Transcutaneous Posterior Tibial Nerve Electrostimulation With Low Dose Trospium Chloride in OAB in Females

Alexandria University30 enrolled

Overview

This study was done to verify whether the combination of transcutaneous posterior tibial nerve stimulation (TPTNS) with low dose trospium chloride in the treatment of females with overactive bladder (OAB) would be more effective than TPTNS alone after failure of behavioral therapy.

The investigators randomized 30 women with OAB, in two groups: G I (15 patients) received 30 minutes TPTNS, three times a week; GII (15 patients) received TPTNS plus Low dose trospium chloride (20 mg once daily); all for 8 weeks. Patients were evaluated using Overactive Bladder Symptom Score questionnaire (OABSS), Incontinence Impact Questionnaire-short form 7 (IIQ-7), 3 day voiding diary and urodynamics at weeks 0 and 8.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

NONE

Enrollment

Conditions

Overactive Bladder

Interventions

TPTNS+DrugCOMBINATION_PRODUCT

one tablet Trospium Chloride 20 mg once daily Plus TPTNS

TPTNSDEVICE

Surface adhesive electrodes placed on the skin above medial malleolus

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Thirty adult female patients having OAB symptoms (wet type) and proved to have detrusor overactivity by urodynamics Exclusion Criteria: 1. Patients having urinary tract infection or bladder outlet obstruction. 2. Patients having neurological diseases. 3. Patients having gynecological problems as genital infection, pelvic organ prolapse or genital tumors. 4. Patients with electronic implants such as heart pacemakers. 5. During pregnancy 6. Patients subject to seizures

Outcomes

Primary Outcomes

Patient satisfaction

Improvement in the questionnaire scores and associated willingness of the patient to continue treatment

Time frame: 1 year

Data from ClinicalTrials.gov

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