The purpose of this research study is to determine the temporal course of recovery of CB1R availability and neural oscillations, in cannabis-dependent individuals at baseline, following 48 hour confirmed inpatient abstinence and after four weeks confirmed abstinence. This research will also examine associations between CB1R availability, neural oscillations and cognitive function.
The purpose of this research study is to determine the temporal course of recovery of CB1R availability and neural oscillations, in cannabis-dependent individuals at baseline, following 48 hour confirmed inpatient abstinence and after four weeks confirmed outpatient abstinence (confirmed by tracking creatinine adjusted urine THC-COOH levels). This research will also examine associations between CB1R availability, neural oscillations and cognitive function using \[11-C\]OMAR PET imaging and electroencephalography.
Study Type
OBSERVATIONAL
Enrollment
162
The radiotracer, \[11-C\]OMAR will be administered at no more than 10 micrograms at the beginning of each PET scan.
Conneticut Mental Health Center
New Haven, Connecticut, United States
CB1R availability using [11-C]OMAR PET imaging
Change in CB1R availability (e.g. volume distribution).
Time frame: Change in CB1R availability from baseline to 48 hours and 28 days
Changes in Cognition during withdrawal using a computerized battery
Changes in cognitive functions such as attention, memory, motor functioning, and processing speed.
Time frame: Change in CB1R availability from baseline to 48 hours and 28 days
Changes in brain rhythms measured by Electroencephalography
Changes in electroencephalographic (EEG) brain rhythms related to information processing.
Time frame: Change in CB1R availability from baseline to 48 hours and 28 days
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