The primary goal of this study is to systematically describe early neurodevelopment using a complementary set of observational and neurophysiological measures that may predict cognitive and motor delays earlier than currently possible for infants with Complex Congenital Heart Disease (CCHD).
The investigators' long-term goals are to develop a method of identifying infants likely to have adverse neurodevelopmental outcomes following neonatal treatment for CCHD and to develop and test interventions that can be applied early in infancy. The necessary first step is to systematically describe early neurodevelopment using a complementary set of observational and neurophysiological measures that may predict cognitive and motor delays earlier than currently possible for infants with CCHD. Each measure provides unique information about development and will include (1) neuroimaging for brain maturity and brain injury, (2) hair and fingernails for cortisol and saliva for immune system function, (3) heart rate variability (HRV) for autonomic nervous system function (ANS), (4) Bayley Scales of Infant Development (BSID-III) for cognitive and motor function, (5) a naturalistic play session incorporating kicking, general movement analysis, or the Test of Infant Motor Performance (TIMP) for motor development, and (6) the mobile paradigm for learning, memory, and task-specific coordination. The investigators will look at types of relationships among these measures within each time point for description of development and across each time point for prediction of development. The investigators' core hypotheses are that infants with CCHD will have measurable deficits in cognitive and motor development birth to \~ 6 months of age when compared with a healthy control group and that a typology developed from neurodevelopmental measures will reliably predict cognitive and motor delay in the first six months of life in infants with CCHD.
Study Type
OBSERVATIONAL
Enrollment
45
Nationwide Children's Hospital
Columbus, Ohio, United States
Change in MRI (Magnetic Resonance Imaging) of brain - infants with CCHD only
Brain MRI
Time frame: 1 to 5 days days prior to surgery, 4-10 days after surgery, 6 months of age
Change in Test of Infant Motor Performance (TIMP)
test of early motor development
Time frame: 0-30 days, 3 months
Change in Mobile Paradigm
Measure of learning, memory, and task-specific kicking coordination in infants
Time frame: 3 months and 6 months
Change in Heart Rate Variability
Measure of autonomic nervous system function and development
Time frame: 30 days, 3 months, 6 months
Bayley Scales of Motor Development
The Bayley Scales of Infant and Toddler Development is an individually administered test designed to assess developmental functioning of infants and toddlers. The Bayley-III assesses development in five areas: cognitive, language, motor, social-emotional, and adaptive behavior.
Time frame: 3 months, 6 months
Edinburgh Postnatal Depression Scale
self report survey to assess maternal depression
Time frame: 0-30 days, 3 months, 6 months
Infant-Toddler Quality of Life Questionnaire
self report survey to assess infant health status and physical and psychosocial functioning
Time frame: 0-30 days, 3 months, 6 months
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State-Trait Anxiety Inventory
sefl report survey measure of anxiety
Time frame: 0-30 days, 3 months, 6 months