Long-term Paired Associative Stimulation as a Treatment for Incomplete Spinal Cord Injury of Non-traumatic Origin

Helsinki University Central Hospital5 enrolled

Overview

The investigators have recently shown in incomplete SCI patients that long-term paired associative stimulation is capable of restoring voluntary control over some paralyzed muscles and enhancing motor output in the weak muscles (1). In this study, the investigators will administer long-term paired associative stimulation to patients with incomplete SCI of non-traumatic origin.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Spinal Cord Diseases Spinal Cord Injuries

Interventions

long-term paired associative stimulationDEVICE

Paired associative stimulation (PAS) administered several times per week for 6 weeks to one hand. PAS comprises transcranial magnetic stimulation (eXimia magnetic stimulator, Nexstim Ltd, Helsinki, Finland) and peripheral nerve stimulation (given with Dantec Keypoint® electroneuromyography device (Natus Medical Incorporated, Pleasanton, CA, USA)).

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * incomplete SCI of non-traumatic origin Exclusion Criteria: * epilepsy * metal inclusion in the head area * pacemaker * hearing device * high intracranial pressure

Locations (1)

BioMag laboratory

Helsinki, Finland

Outcomes

Primary Outcomes

Daniels and Worthingham's Muscle Testing

each hand muscle is evaluated on 0-5 scale

Time frame: 2 days after the last stimulation session

Daniels and Worthingham's Muscle Testing

each hand muscle is evaluated on 0-5 scale

Time frame: 1 month after the last stimulation session

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.