Intravenous infusion of dexmedetomidine during procedure was known to be associated prolonged duration of spinal anesthesia. In patients receiving dexmedetomidine infusion during procedure, it has been not evaluated whether use of adjuvant intrathecal fentanyl had additional prolonging effect on duration of spinal anesthesia or not. Therefore, the investigators planned this trial to compare clinical outcomes in patients receiving spinal anesthesia with heavy bupivacaine only and heavy bupivacaine plus fentanyl adjuvant.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
56
intrathecal fentanyl will be added as adjuvant for spinal anesthesia using heavy bupivacaine, while dexmedetomidine will be infused intravenously during operation
heavy bupivacaine will be injected intrathecally during spinal anesthesia, without fentanyl, while dexmedetomidine will be infused intravenously during operation
Seoul National University Hospital
Seoul, South Korea
Two segment sensory block regression time
Time from highest sensory block level to two segment regression
Time frame: From completion of spinal anesthesia, to end of surgery, an expected average of 2 hours
motor block
modified Bromage scale
Time frame: From completion of spinal anesthesia, to end of surgery, an expected average of 2 hours
postoperative pain score
VAS scale
Time frame: at op day, at postoperative 1st day, at postoperative 2nd day
postoperative nausea and vomiting
VAS scale
Time frame: at op day, at postoperative 1st day, at postoperative 2nd day
intraoperative incidence of hypotension
hypotension : SBP decreased by more than 30% of baseline SBP
Time frame: From completion of spinal anesthesia, to end of surgery, an expected average of 2 hours
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