Chronic Pain, especially neuropathic pain, are adverse events after posterolateral thoracotomy for lung resection. The continuous application of ketamine may have a prophylactic effect and helps to prevent chronic pain. The investigators record the incidence and severity of acute pain and neuropathic pain during a seven day period after thoracotomy as well as the incidence of chronic pain and neuropathic pain after one and three month period. Parallel Group design, comparing one Group with a continuous application (24 hours) of ketamine against a Placebo Group.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
200
Normal saline applied by bolus before operation started, followed by a continuous application of normal saline for 24 hours.
Application of Ketamine 0,2mg/kg ideal Body weight by Bolus before the Operation started, followed by application of 0,2 mg/kg ideal Body weight for 24 hours.
Dr. Horst Schmidt Klinik
Wiesbaden, Hesse, Germany
Change in perioperative opioid consumption
The patients consumption of opioids is recorded once a day for a period of 7 days after operation.
Time frame: seven days after operation
Change in acute pain
The incidence and severity of pain will be measured using a numeric analog scale (NAS) once a day for a period of seven days after Operation.
Time frame: 7 days after Operation
acute neuropathic pain
The incidence of neuropathic pain will be measured using the LANSS Pain Scale (Leeds assessment of neuropathic symptoms and signs) three and seven days after operation
Time frame: 7 days after operation
Change in chronic Pain
The incidence and severity of pain will be measured using a numeric analog scale (NAS). Pain scale is requested by phone one and three month after Operation.
Time frame: one and three month after operation
Chronic Neuropathic pain
The incidence of neuropathic pain will be measured by using the LANSS Pain Scale (Leeds assessment of neuropathic symptoms and signs) one month after operation
Time frame: one month after operation
Chronic Neuropathic Pain
The incidence of neuropathic pain will be measured by using the LANSS Pain Scale (Leeds assessment of neuropathic symptoms and signs) three month after operation
Time frame: three month after operation
recovery time
Time between stopping intravenous anaesthesia and first eye opening of the Patient in minutes
Time frame: eye opening after stopping anesthesia in minutes
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