Irreversible Electroporation (NanoKnife) for the Treatment of Pancreatic Adenocarcinoma

Inclusion Criteria: * Patients with histologically proven adenocarcinoma of the head of the pancreas (fine needle aspiration or biopsy) * Pancreatic adenocarcinoma locally advanced on imaging at diagnosis * Tumor of less than 7 cm in largest diameter * No chemotherapy or abdominal radiotherapy within five years before the inclusion in the study Exclusion Criteria: * Pancreatic adenocarcinoma of more than 7 cm of diameter or immediately operable on imaging data * Patient with contraindication of NanoKnife use * Patient with neurostimulator * Epileptic patient or with a myocardial infarction lasting less than 2 months * Presence of visceral or lymph node metastases or peritoneal carcinosis at the initial workup * Patient who cannot be treated with muscle blockers (curare) * Patient with a metallic stent or a medical device implanted near the area treated by electroporation