For patients with active moderate-to-severe thyroid associated ophthalmopathy (TAO), the Intravenous Glucocorticoids (GCs) is the recommended therapy. However, the efficacy of GCs is not satisfied. Investigators established a novel classification of TAO for the first time to assess more precisely for better personal treatment.
TAO is one of most common extra thyroid manifestation of dysfunctional thyroid disease. Since the morbidity of TAO has been increasing rapidly, Investigators' team is intended to verify the feasibility of the new type of classification system established by the related parameters of orbital MRI scan. Based on classification, investigators compare the efficacy of two GCs therapy. According to MRI,investigators measure the optimal T2 signal intensity ratio (SIR) for the treatment of TAO, which may help to find a better treatment time for therapy.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
200
Intravenous Glucocorticoids (GCs)
the Third Affiliated Hospital of Southern Medical University
Guangzhou, Guangdong, China
RECRUITINGNumber of patients defined as Response for the Glucocorticoids Treatment based on the 7 parameters of eye assessment
"Response" was defined as at least three of the following outcome measures: 1. reduction in lid width by at least 3 mm; 2. reduction in any of the class 2 NOSPECS signs by at least two grades; 3. reduction in proptosis by at least 2 mm; 4. reduction in intraocular pressure by at least 2 mm Hg; 5. improvement in CAS by at least two points; 6. improvement in diplopia (disappearance or degrade in degree); 7. improvement in visual acuity by 1 Snellen line.
Time frame: 2years
Number of patients defined as Deterioration for the Glucocorticoids Treatment based on the 7 parameters of eye assessment
"Deterioration" of each parameter was defined as follows: 1. increase in lid width by at least 3 mm; 2. increase in any of the class 2 NOSPECS signs by at least two grades; 3. increase in proptosis by at least 2 mm; 4. increase in intraocular pressure by at least 2 mm Hg; 5. increase in CAS by at least two points; 6. increase in diplopia (new onset or upgrade in degree); 7. decrease in visual acuity by 1 Snellen line.
Time frame: 2years
Number of patients defined as Unchange for the Glucocorticoids Treatment based on the 7 parameters of eye assessment
"Unchanged" was defined as no change or changes smaller than previously defined in any of the mentioned parameters.
Time frame: 2years
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