The Association Between Variation in Oxygen Saturation (ScO2) and Incidence of Postoperative Cognitive Dysfunction (POCD) in a Population of Elderly Patients Admitted for Emergency Surgery.

Centre Hospitalier Universitaire, Amiens300 enrolled

Overview

There is no study of the association between ScO2 and POCD in non-cardiac, thoracic or vascular surgery. The few studies found in cardiac, thoracic and vascular surgery show an incidence up to 50% with a variation of the ScO2 threshold which varies between 15 and 25% according to the studies. Age is the main risk of OCDD. The management of this pathology should be early to avoid loss of autonomy of the patient. Finding a relationship, if it exists, would therefore significantly improve the mortality and morbidity of the said patient.

Study Type

INTERVENTIONAL

Allocation

Purpose

OTHER

Masking

NONE

Enrollment

300

Conditions

Cerebral Saturation Cognitive Impairment Emergencies

Interventions

Evaluate the relationship between oxygen saturation and the incidence of postoperative cognitive dysfunction in non-cardiac, thoracic and vascular emergency surgery in patients 65 years of age and older. The occurrence of POCD will be defined by the MMSE decrease of at least 4 points at 24, 48 or 72 hours

Eligibility

Sex: ALLMin age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age ≥ 65 years * Non-cardiac, thoracic and vascular emergency surgery * Surgery under general anesthesia * ASA I, II or III * Simple information without consent * Patient affiliated to social security Exclusion Criteria: * Inability to understand * Patient under tutelage, or curatorship or deprived of public right * ASA IV * History of severe dementia MMSE \<20 * Personal or familial history of malignant hyperthermia * History of allergy or hypersensitivity to anesthetic products used * Contra-indication to Cisatracurium®: myasthenia gravis * Contra-indication to Sevoflurane® * Contra-indication to local anesthetics * Indication of use of a Ketamine®-type hypnotic (modification of the BIS) * Indication of use of nitrous oxide * History of cranial trauma * Neuromuscular pathology * Spinal anesthesia * Cardiac, thoracic or vascular surgery * Surgery not performed in emergency * Neurochirugia in the context of cranial trauma * Any surgery that does not allow the use of the NIRS (impossibility of positioning of the electrodes by the location of the surgical field).

The Association Between Variation in Oxygen Saturation (ScO2) and Incidence of Postoperative Cognitive Dysfunction (POCD) in a Population of Elderly Patients Admitted for Emergency Surgery.

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Central Contacts