The investigators studied whether scalp hair cortisol and testosterone levels differed between sarcoidosis patients both with and without fatigue and healthy controls.
Rationale: Fatigue is a common symptom in patients with sarcoidosis and has great impact on quality of life. Several aspects in the pathogenesis of sarcoidosis and co-morbidities accompanying sarcoidosis could contribute to fatigue. However, until now the etiology of fatigue in sarcoidosis is unknown. Measurements of steroid hormones in scalp hair could possibly be directional in elucidating the underlying mechanism and could also be used as a screening and follow up tool in interventional studies. Objective: A pilot to investigate whether cortisol and testosterone levels measured in hair differ between patients with sarcoidosis related fatigue, sarcoidosis patients without fatigue and healthy subjects. Study design: A prospective observational study, using hair samples of sarcoidosis patients with and without fatigue, compared to an already existing age matched healthy control group. Study population: Adult sarcoidosis patients at the outpatient clinic of the pulmonary department of the Erasmus MC, Rotterdam Main study parameters/endpoints: Cortisol and testosterone levels in scalp hair, correlation with Fatigue Assessment Scale.
Study Type
OBSERVATIONAL
Enrollment
32
Scalp hair cortisol differences between sarcoidosis patients with and without fatigue and healthy controls
Differences between patients with sarcoidosis related fatigue, sarcoidosis patients without fatigue, and healthy controls
Time frame: 1 month
Scalp hair testosterone differences between sarcoidosis patients with and without fatigue and healthy controls
Differences between patients with sarcoidosis related fatigue, sarcoidosis patients without fatigue, and healthy controls
Time frame: 1 month
Scalp hair cortisone differences between sarcoidosis patients with and without fatigue and healthy controls
Differences between patients with sarcoidosis related fatigue, sarcoidosis patients without fatigue, and healthy controls
Time frame: 1 month
Fatigue Assessment Scale (FAS)
A short validated questionnaire to assess fatigue in sarcoidosis, and its relation to scalp hair steroids
Time frame: 1 day
King's Sarcoidosis Questionnaire (KSQ)
A validated questionnaire to assess sarcoidosis-related health status, and its relation to scalp hair steroids
Time frame: 1 day
EuroQol-5D-5L (EQ-5D-5L)
A validated generic questionnaire to assess general health status, and its relation to scalp hair steroids
Time frame: 1 day
Short Form-36 (SF-36)
A validated generic questionnaire to assess health-related quality of life, and its relation to scalp hair steroids
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Time frame: 1 day
Perceived Stress Scale
A validated questionnaire to assess perception of stress, and its relation to scalp hair steroids
Time frame: 1 day
Hospital Anxiety and Depression Scale
A validated questionnaire to identify presence of depression and anxiety, and their relation to scalp hair steroids
Time frame: 1 day
% predicted forced vital capacity (FVC)
To assess the relationship between scalp hair steroids and FVC
Time frame: 1 day
% predicted diffusion capacity of carbon monoxide (DLCO)
To assess the relationship between scalp hair steroids and DLCO
Time frame: 1 day
6-minute walk distance test (6MWT)
To assess the relationship between scalp hair steroids and 6MWT
Time frame: 1 day
Waist circumference
To assess the relationship between scalp hair steroids and waist circumference
Time frame: 1 day
Body Mass Index (BMI)
To assess the relationship between scalp hair steroids and BMI
Time frame: 1 day