The incidence rate of ground-glass opacity (GGO) has been increasing these years. A great number of retrospective studies suggested that sublobar resection was better for some GGO patients. However, no prospective clinical study supports the perspective. This study is prospective, multi-center, randomized-controlled. The aim of this study is to investigate whether sublobar resection is inferior to lobectomy for cT1N0M0 non-small-cell lung cancer or not.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
600
Patients receive sublobar resection, which includes wedge resection and segmentectomy.
patients receive lobectomy
Shanghai Zhongshan Hospital
Shanghai, Shanghai Municipality, China
RECRUITINGOverall Survival
survival status of patients after surgery
Time frame: five years after surgery
Disease Free Survival
recurrence status of patients after surgery
Time frame: five years after surgery
Local and distant recurrence rates
recurrence rate of local and distant locations respectively
Time frame: five years after surgery
Pulmonary Function: forced expiratory volume in 1 second (FEV1) in liter
FEV1 of patients after surgery
Time frame: 3rd, 6th, 12th, and 24th month after surgery
Pulmonary Function: forced vital capacity (FVC) in liter
FVC of patients after surgery
Time frame: 3rd, 6th, 12th, and 24th month after surgery
Pulmonary Function: diffusing capacity of the lungs for carbon monoxide (DLCO) in mL/min/mmHg
DLCO of patients after surgery
Time frame: 3rd, 6th, 12th, and 24th month after surgery
Morbidity rate
the rates of complications related to treatment during perioperative period
Time frame: up to 30 days after surgery
Mortality rate
the rates of death related to treatment during perioperative period
Time frame: up to 30 days after surgery
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