The study investigates whether Therapeutic Drug Monitoring (TDM) and continuous infusion (CI) of beta-lactam antibiotics optimises target concentrations in patients with bacteraemia.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Beta-lactam antibiotic will be administered as continous infusion.
Dosage of beta-lactam antibiotics will be adjusted according to serum concentration.
Target concentrations.
Serum concentrations within the target values for intervention. Following beta-lactams is included in the study: Benzylpenicillin, ampicillin, dicloxacillin, piperacillin/tazobactam, cefuroxime and meropenem.
Time frame: 30 days after intervention.
Morbidity.
Diagnoses compared between the two arms.
Time frame: 30 days after intervention.
Number of days until medically discharged.
Number of days until medically discharged compared between the two arms.
Time frame: 30 days after intervention.
Failed antibiotic treatments.
Adding an additional antibiotic and/or change to a different antibiotic (not including a more narrow spectrum antibiotic) compared between the two arms.
Time frame: 30 days after intervention.
Amount of antibiotic used.
Defined daly doses of antibiotic therapy compared between the two arms.
Time frame: 30 days after intervention.
Antibiotic side effects and complications.
The severity of bacteraemia, mechanical ventilation and start-up of dialysis compared between the two arms. Growth of antibiotic-associated pathogenic in patient material compared between the two arms.
Time frame: 30 days after intervention.
Mortality.
30-day mortality compared between the two arms.
Time frame: 30 days after intervention.
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Number of participants with abnormal clinical data and/or abnormal laboratory values.
Clinical data includes height, weight, heart rate, blood pressure, respiratory rate, Glasgow Coma Scale score, body temperature, fous of infection, the severity of bacteraemia, dialysis and laboratory values includes hemoglobin, white blood cells, neutrophils, thrombocytes, C-reactive protein, sodium, potassium, creatinine, albumin, lactate dehydrogenase, alanine amino transferase and lactate. Both will be compared between the two arms.
Time frame: 30 days after intervention.