L-carnitine and plus metformin in clomiphene-resistant obese PCOS women, reproductive and metabolic effect: a randomized clinical trial
the trial aims to compare L-carnitine and plus metformin in clomiphene-resistant obese PCOS women with placebo to state the reproductive and metabolic effects in form of pregnancy and insulin resistance parameters and lipid metabolism.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
280
L-carnitine plus Metformin was given Obese PCOS Women trying induction of ovulation with clomiphene citrate.
placebo was given Obese PCOS Women trying induction of ovulation with clomiphene citrate.
Zagazig University
Zagazig, Egypt
pregnancy rate
number of women with clinical pregnancy
Time frame: 3 momths
ovulation rate
number of women with follicle \>18mm.
Time frame: 3 momths
abortion rate
number of women with abortions
Time frame: 3 momths
insulin resistance
fasting glucose and insulin
Time frame: 3 momths
lipid metabolism
Triglyceride, cholesterol
Time frame: 3 momths
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