Build-up of Action Representation in Autism Spectrum Disorders

Hospices Civils de Lyon54 enrolled

Overview

Autistic spectrum disorders (ASD) are highly debilitating developmental syndromes which core feature is social and communications disorders. Motor skill impairments are frequently described in autism, but few studies have addressed the question of their origin and their specificity. Furthermore, it is not clear whether motor problems encountered in autism are related to dyspraxia, or if they present with specific features. This project aims at deciphering the origin of motor problems encountered by children who grow-up with autism in order to propose early interventions that could influence the other developmental trajectories, such as the social one. Brain dynamics during sensori-motor learning is explored by applying magnetoencephalography (MEG) during the Bimanual Load-Lifting paradigm. Different motor processes namely: proprioceptive monitoring, use and update of a sensori-motor representation, anticipatory executive control will be correlated to brain oscillation modulation, both topographically and temporally. Two groups of children (aged between 7 and 12) are compared: a group of children with ASD and a control group of typically developing children.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Healthy Autism Spectrum Disorder

Interventions

Behavioral assessmentsOTHER

Kinematics measures, concomitant to Magnetoencephalography (MEG, measures oscillatory rhythms in the brain) and Magnetic Resonance Imaging (MRI, used to provide an anatomical image of each participant's brain to be coregistered with oscillatory measurements) recordings, enable to track sensori-motor learning based on performance, and oscillatory changes (with high temporal and spatial resolution).

Magnetoencephalography (MEG)OTHER

Magnetic Resonance Imaging (MRI)OTHER

Eligibility

Sex: ALLMin age: 7 YearsMax age: 12 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Control group: children aged between 7 and 12 * Case group: children aged between 7 and 12 with a diagnostic of Autism Spectrum Disorders Exclusion Criteria: * Control group: presence of a neurological pathology, mental retardation or language and motor developmental delay * Case group: presence of a neurological pathology, mental retardation

Outcomes

Primary Outcomes

Changes of cerebral oscillations in three frequency bands (alpha, beta, gamma) during sensori-motor learning.

Oscillatory measures are computed in the sensor and source space in order to identify the regions involved in the sensori-motor learning in the control group and in the ASD group.

Time frame: Day 1

Secondary Outcomes

Correlation between oscillatory measures and learning performance.

Kinematic recordings enable to measure the learning performance at the end of the experiment. This measure will be correlated with oscillatory changes during the task.