HILO-HF Registry: High Versus Low SpO2 Oxygen Therapy in Patients With Acute Heart Failure

University of Alberta60 enrolled

Overview

The HILO-HF Registry is a single centre registry that will be performed to provide information on the usual baseline oxygen saturation (SpO2) in patients presenting to ED with a primary ED diagnosis of AHF

Study Type

OBSERVATIONAL

Enrollment

Conditions

Acute Heart Failure

Eligibility

Sex: ALLMin age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients \>40 years of age presenting to the ED with AHF * With or without tested BNP * With or without admission to hospital for treatment of HF\\ * Patients must be recruited within the first 24 hours of presenting to the ED. Exclusion Criteria: * Patients on home oxygen * Patients with known prior hypercapnic failure (PaCO2\>50 mmHg) * Asthma * Primary pulmonary hypertension * Patients requiring urgent positive pressure ventilation or intubation or on \>10 L/min oxygen

Locations (1)

University of Alberta Hospital / Mazankowski Alberta Heart Institute

Edmonton, Alberta, Canada

Outcomes

Primary Outcomes

Change in blood oxygen saturation levels from baseline to 72 hours

Time frame: 72 hours

Secondary Outcomes

Dyspnea on visual analogue scale (VAS) to 72 hours

Time frame: 72 hours

Change in global symptoms using Patient Global Assessment (PGA) measure to 72 hours

Time frame: 72 hours

Change in Peak Expiratory Flow

Time frame: 72 hours

Rate of patients with Worsening Heart Failure

Time frame: 7 days

30-day composite clinical event (all-cause mortality, HF readmission, days alive and out of hospital)

Time frame: 30days

Data from ClinicalTrials.gov

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