Short-term Efficacy of Antidepressant in Patients Underwent TKA

Dalian Municipal Central Hospital32 enrolled

Overview

By taking certain antidepressant in early postoperative period，which is supposed to improve the psychological status of patients with osteoarthritis, explore the effect of certain antidepressant on the recovery of the early stage after the operation of knee joint replacement.

In this study, the investigators are going to investigate the efficacy of Duloxetine on pain, physical function, mental health and quality of life in patients underwent TKAs. The control group is going to be given celecoxib 200mg/24h to 2 weeks after operation.On the basis of the above scheme, the treatment group is going to receiving duloxetine 60mg/24h to 8 weeks after operation.HAMD-17 scale, KSS scale, SF-36 scale and WOMAC scale will be used to evaluate the two groups before and after operation for 4 and 8 weeks.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Osteoarthritis Of Knee

Interventions

Duloxetine HydrochlorideDRUG

The treatment group will receive duloxetine 60mg/24h to 8 weeks after operation

Eligibility

Sex: ALLMin age: 51 YearsMax age: 85 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. No extra articular malformations are diagnosed and accord with Kellgren-Lawrence criteria 2. Primary TKA surgery,Varus is smaller than 20° 3. Always there is no history of mental illness, no history of relevant medicine 4. Be able to read and understand Chinese, with good communication skills 5. Voluntary participation in this clinical study Exclusion Criteria: 1. Previous history of mental and psychological illness 2. With severe diseases in respiratory system, circulatory system or digestive system 3. Allergic to duloxetine and celecoxib

Locations (1)

Dalian municipal central hospital

Dalian, Liaoning, China

Outcomes

Primary Outcomes

Pain score of participants with Duloxetine as assessed by Western Ontario and McMaster Universities Index after 4 weeks of treatment.

A face-to-face questionnaire will be conducted by two trained interviewers

Time frame: up to 6 months

Function score of participants with Duloxetine as assessed by Knee Society Score after 4 weeks of treatment.

A face-to-face questionnaire will be conducted by two trained interviewers

Time frame: up to 6 months

Secondary Outcomes

Pain score of participants with Duloxetine as assessed by Western Ontario and McMaster Universities Index after 8 weeks of treatment.

A face-to-face questionnaire will be conducted by two trained interviewers

Time frame: up to 6 months

Function score of participants with Duloxetine as assessed by Knee Society Score after 8 weeks of treatment.

A face-to-face questionnaire will be conducted by two trained interviewers

Time frame: up to 6 months

Data from ClinicalTrials.gov

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