Study Evaluating Safety, Tolerability and Pharmacokinetics of EYP001a in Healthy Male Subjects

Inclusion Criteria: \- Subjects must satisfy all of the following inclusion criteria during screening to be enrolled in the study: 1. Subject has given voluntary written informed consent before performance of any study related procedure 2. Subject must be 18 to 50 years of age, inclusive at screening 3. Subject must have clinical chemistries, hematology, and urinalysis tests within normal, allowable limits (if out of range must be considered clinically significant to be exclusionary) and performed within 21 days of receiving first dose of study drug 4. Subject must have a body mass index of between 18 and 30 kg/m2 at screening 5. Subject must have weight \> 60 kg at screening 6. Subject must have normal vital signs after 5 minutes resting in supine position at screening: * 95 mm Hg \< systolic blood pressure \< 140 mm Hg * 45 mm Hg \< diastolic blood pressure \< 90 mm Hg * 40 bpm \< pulse rate \< 90 bpm 7. Subject must have a normal 12-lead automatic ECG (incomplete right bundle branch block can be accepted): 120 ms \< PR \< 210 ms, QRS \< 120 ms, corrected QT interval (QTc) (Fridericia) ≤ 450 msec at screening. 8. Agree to abstain from all medication, including non-prescription and prescription medication (including vitamins and natural or herbal remedies, e.g. St. John's Wort) for 21 days before the first study day until discharge from the study (end of post study medical). 9. Subject agrees to use condom from dosing through 90 days after the dose of study drug. Female partners of male subjects enrolled into this study are also recommended to use an acceptable method of birth control (i.e., a hormonal contraceptive, intra-uterine device,diaphragm, condom, or abstinence). Exclusion Criteria: \- Subjects meeting any of the following exclusion criteria are not to be enrolled in the study: 1. A history of clinically significant gastrointestinal, especially peptic ulcerations, gastrointestinal bleeding, ulcerative colitis, cholecystectomy, Crohn's disease or Irritable Bowel Syndrome, renal, hepatic, neurologic, hematologic, endocrine, oncologic, pulmonary, immunologic, psychiatric, especially those with a past history of depression, suicidal ideation or suicidal attempts, or cardiovascular disease or any other condition which, in the opinion of the principle investigator, would jeopardize the safety of the subject or impact the validity of the study results 2. Acute diarrhea or constipation in the 7 days before the predicted first study day. If screen occurs \>7 days before first study day, this criterion will be determined on first study day. Diarrhea will be defined as the passage of liquid feces and/or a stool frequency of \> 3 times per day. Constipation will be defined as a failure to open the bowels more frequently than every other day 3. Donation or loss of more than 100 mL of blood within 60 days prior to the first drug administration 4. Regular alcohol consumption \>21 units per week (1 Unit = 1⁄2 pint beer, 25 mL shot of 40% spirit or a 125 mL glass of wine) 5. Subject has a borderline or long QTc Fridericia interval as defined by screening readings of \> 450 6. Subject has participated in a drug study within 60 days prior to the first drug administration in the current study 7. Subject has used any over-the-counter (OTC) medication, including vitamins, within 21 days prior to the study 8. Subject has used any prescription medication within 21 days prior to the study 9. Subject has been treated with any known P450 3A4 or 2D6 enzyme altering drugs within 30 days prior to the study 10. Subject smoking more than 5 cigarettes per day 11. Subject has sought advice from or been referred to a general practioner or counselor for abuse or misuse of alcohol, non-medical drugs, medicinal drugs or other substance abuse, e.g. solvents 12. Subject has a positive blood screen for HIV, Hepatitis B surface antigen (HBsAg), and Hepatitis C Antibody and/or a positive urine screen for alcohol or drugs of abuse 13. Any current or previous use of drugs such as opiates, cocaine, ecstasy, or intravenous amphetamines \- Subjects who admit to occasional past use of cannabis will not be excluded as long as they have a negative drugs-of-abuse test and have been abstinent from cannabis use for at least 3 months 14. Subject has an uncontrolled inter-current illness (i.e., active infection) 15. Subject has had major surgery within four weeks of study entry, or 12 months prior to study for gastrointestinal surgery.