Randomized Double-blind Study on the Treatment of Osteoarthritis of the Bilateral Knee: Autologous Bone Marrow Concentrate vs. Hyaluronic Acid

Inclusion Criteria: 1. Male or female patients, aged between 18 and 75 years; 2. Bilateral symptomatic knee osteoarthritis (Kellgren-Lawrence grade 1-4); 3. Failure after two months of conservative treatment; 4. Capacity and consent of patients to participate actively in the rehabilitation protocol, follow-up clinic and radiology protocol; 5. Signature of informed consent. Exclusion Criteria: 1. Patients incapable of discernment; 2. Patients with malignancy 3. Patients with rheumatic diseases; 4. Patients with diabetes; 5. Patients with metabolic disorders of the thyroid; 6. Patients belonging abuse of alcohol, drugs or medications; 7. Patients with misalignment of the lower limbs than 10 °; 8. Body Mass Index\> 40; 9. Patients with a history of trauma or intra-articular infiltration of therapeutic substances within 6 months prior to treatment.