Efficacy of Coenzyme q10 in Pediatrics With Type 1 Diabetes Mellitus

Ain Shams University49 enrolled

Overview

The purpose of this study is to determine wether coenzyme Q10 is effective in reducing markers of endothelial dysfunction in pediatric patients with type 1 diabetes mellitus and aslo to investigate its effect on glycemic control and lipid profile of those patients and its effect on patient's quality of life.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Diabetes Mellitus, Type 1

Interventions

Coenzyme Q10DIETARY_SUPPLEMENT

Coenzyme Q10 soft gelatin capsule 100mg

InsulinDRUG

multiple dose insulin injection therapy

Eligibility

Sex: ALLMin age: 8 YearsMax age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Age: patients from 8 to 18 years old. 2. Outpatient with at least 1 year history of type 1 diabetes mellitus. 3. Insulin requirement of more than or equal 0.5 U/Kg/day. 4. Approval to participate and give informed consent. Exclusion Criteria: 1. Presence of systemic disorders such as celiac disease, hypothyroidism or hyperthyroidism. 2. Preexisting cardiovascular disease or hypertension. 3. Chronic kidney disease or chronic liver disease. 4. Significant mental illness. 5. Intake of other antioxidants such as ascorbic acid and α-tocopherol and omega3 supplement within the last 3 months. 6. Intake of coenzyme Q10 within the last 3 months.

Locations (1)

Ainshams university pediatric's hospital

Cairo, Egypt

Outcomes

Primary Outcomes

change in soluble interacellular adhesion molecule level

it will be assessed at baseline and after three months of treatment

Time frame: three months

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.