Study for the Treatment of the Bone Marrow Edema:Core Decompression VS Bone Marrow Concentrate (BMC) VS Bone Substitute

Inclusion Criteria: 1. Male or female patients between 18 and 75 years; 2. Symptomatic subchondral bone marrow lesions of femoral condyles (grade ≥ 1 according to the WORMS MRI score); 3. Failure after at least two months of a conservative treatment; 4. Single BME areas involving a single compartment of the knee; 5. Availability of the patients to participate actively in the rehabilitation protocol and follow-up clinic and radiology; 6. Signature of informed consent. Exclusion Criteria: 1. Patients incapable of discernment; 2. History of allergy to calcium phosphates; 3. Patients with malignancies; 4. Patients with rheumatic diseases; 5. Patients with diabetes; 6. Patients suffering of metabolic disorders of the thyroid; 7. Patients with history of abuse of alcohol, drugs or medication; 8. Patients with advanced osteoarthritis (Kellgren-Lawrence grade\> 3); 9. Body Mass Index\> 35; 10. BME that involve more than one compartment; 11. Patients with trauma in the 6 months prior to the intervention. -