The Effects of Energy Imbalance on Food Intake Behaviors

University of Colorado, Denver76 enrolled

Overview

This study will determine whether changes in energy balance alter regional neuronal activation of brain regions associated with food intake in individuals screened to be either resistant or prone to obesity. Specifically, it will determine whether foods of "hedonic" value elicit changes in regional neuronal activity in the fasted and fed state in "obese-resistant" and "obese-prone" men and women in varying states of energy balance.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

OTHER

Masking

NONE

Enrollment

Conditions

Obesity

Interventions

Eucaloric Feeding PeriodOTHER

Overfeeding Feeding PeriodOTHER

Underfeeding Feeding PeriodOTHER

Eligibility

Sex: ALLMin age: 25 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: In the obese-prone group: * BMI between 20-30 * Report at least one obese first-degree relative * Self-describe as "struggling" with weight * Weight-stable for at least 3 months prior to study participation In the obese-resistant group: * BMI between 17-25 * Report no obese first-degree relatives * Self-describe as "naturally thin" and have never been overweight * Overall weight stability Exclusion Criteria: * Significant medical or psychiatric disease * History of eating disorder * Left handed * Unable to complete an MRI scan (e.g., metal in body, claustrophobic)

Locations (1)

University of Colorado Anschutz Medical Campus

Aurora, Colorado, United States

Outcomes

Primary Outcomes

Change in neuronal response to food vs. nonfood objects in fasted vs. fed states

Change in neuronal response to food vs. nonfood objects in the overfed and underfed feeding periods as compared to the eucaloric period between fasted and fed states in obese-prone as compared to obese-resistant individuals.

Time frame: Day 5 of each of the three 5-day study periods (Eucaloric, Overfeeding, Underfeeding)

Secondary Outcomes

Change in appetite ratings

Change in appetite ratings via visual analog scale (VAS; 0-100) before vs. after a meal in the overfeeding and underfeeding periods compared to the eucaloric feeding periods between obese-resistant and obese-prone individuals.

Time frame: At baseline, in the fasted state on Day 5 of each of the three 5-day study periods (Eucaloric, Overfeeding, Underfeeding) and at 30, 90, 120, 150 and 180 minutes after a meal on Day 5 of each of the three 5-day study periods.

Change in food cravings

Change in food cravings (questionnaire) before vs. after a meal in the overfeeding and underfeeding periods compared to the eucaloric feeding periods between obese-resistant and obese-prone individuals.

Time frame: At baseline and both before and after a meal on Day 5 of each of the three 5-day study periods (Eucaloric, Overfeeding, Underfeeding).

Change in leptin levels

Change in blood leptin levels before vs. after a meal in the overfeeding and underfeeding periods compared to the eucaloric feeding periods between obese-resistant and obese-prone individuals.

Change in ghrelin levels

Change in blood ghrelin levels before vs. after a meal in the overfeeding and underfeeding periods compared to the eucaloric feeding periods between obese-resistant and obese-prone individuals.

Data from ClinicalTrials.gov

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