Muscle Elastography in Spastic Cerebral Palsy

Hospital for Special Surgery, New York16 enrolled

Overview

To date, clinical tests are unable to differentiate between the cause of muscle stiffness, although a manual instrumented spasticity assessment for the lower limb that utilizes surface electromyogram has recently been proposed. This study intends to use shear wave elastography to assess individual muscle stiffness parameters and the individual response to botulinum toxin injection in the elbow and wrist flexors. Collection of baseline spasticity parameters could then be used to predict the effect of botulinum toxin type A and ultimately serve as a basis for development of a treatment model for muscle spasticity in patients with spastic cerebral palsy.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Unilateral Spastic Cerebral Palsy

Interventions

Botulinum toxin type ADRUG

Botox injection in upper extremity for spasticity in pediatric CP patients

Eligibility

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with unilateral spastic cerebral palsy with presence of dynamic muscle spasticity in the elbow and/or wrist flexors, who will be able to provide consent. * Consent may be obtained from a parent or legal guardian, as applicable. Exclusion Criteria: * Prior surgical procedure in the affected upper extremity * Unrelated orthopedic injury to the affected upper extremity * Current oral or intrathecal antispasticity therapy * Prior Botulinum toxin type A injection in preceding 6 months

Outcomes

Primary Outcomes

Muscle Elasticity

Change in muscle elasticity (in kilopascal )

Time frame: From immediate pre-injection to 1 month post-injection.

Muscle Elasticity

Change in muscle elasticity (in m/s)

Time frame: From immediate pre-injection to 1 month post-injection.

Secondary Outcomes

Functional measures

Functional measures (MAS)

Time frame: immediately pre- and immediately post-injection, and at 1 month, 3 months and 6 months post-injection.