A Comparison of Optimal PEEP Determination Guided by EIT and G5 Device in Moderate and Severe ARDS Patients

Mei-Yun Chang88 enrolled

Overview

To Select the Optimal Positive End-expiratory Pressure in Moderate and Severe Acute Respiratory Distress Syndrome Patients by Using: 1. the novel Non-invasive Electrical Impedance Tomography Guided Method 2. the Protective ventilation tool G5(MV)

1. To titrate PEEP guided by EIT. A global inhomogeneity (GI) index and regional compliance based on EIT were developed to quantify the tidal volume distribution within the lung. The aim of this study was to test the feasibility of optimizing PEEP with respect to ventilation homogeneity using the GI index and regional compliance. 2. To titrate PEEP with the Protective Ventilation Tool by G5(MV). The new generation of ventilator will deliver an optimal PEEP on ARDS patients based on their status automatically.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

NONE

Enrollment

Conditions

Acute Respiratory Distress Syndrome

Interventions

optimal PEEP guided by EITDEVICE

Patients are randomly assigned to EIT group or G5 group. PEEP selected in EIT group is based on GI index and regional compliance. PEEP decided in G5 group is based on the ventilator.

optimal PEEP guided by G5 ventilatorDEVICE

Patients are randomly assigned to EIT group or G5 group. PEEP selected in EIT group is based on GI index and regional compliance. PEEP decided in G5 group is based on the ventilator.

Eligibility

Sex: ALLMin age: 20 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. ARDS patients 2. Transferred from FEMH emergency room or Ward into the medical intensive care unit. 3. Patients with invasive mechanical ventilation 4. Patient, agent or consent of families learn about and subjects were willing to sign the consent form. Exclusion Criteria: 1. burning electric knife used 2. pacemaker used 3. Large area wound is used gauze to cover 4. Wound or burn injuries of the chest wall. 5. Patients included conditions are not met.

Locations (1)

Electrical impedance tomography (EIT)

New Taipei City, No.21, Sec. 2, Nanya S. Rd., Banciao Dist, Taiwan

Outcomes

Primary Outcomes

Respiratory system parameter

Compliance

Time frame: 48 hrs

Secondary Outcomes

MV day

Number of days with ventilator and ICU stay

Time frame: 64 days

Respiratory system parameter

PaO2/FiO2

Time frame: 48 hrs

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.