The 3D Cohort Study (Design, Develop, Discover)

N/AActive Not RecruitingNCT03113331

Université de Sherbrooke2,366 enrolled

Overview

The 3D Cohort Study (Design, Develop, Discover) was established to help bridge knowledge gaps about the links between various adverse exposures during pregnancy with birth outcomes and later health outcomes in children.

The main objective of the 3D study is to create a large pregnancy and birth cohort, allowing for the assessment of the effects of combined prenatal exposure on both birth outcomes and longer-term infant and child health. The specific objectives are to: 1. Determine the effects of pre- and post-natal exposures to environmental contaminants, nutritional factors and psychosocial stress on pregnancy and neurodevelopmental outcomes; 2. Assess the contribution of social, genetic, epigenetic, nutritional and environmental factors to the etiology and outcomes of intrauterine growth restriction (IUGR) and preterm birth; and 3. Assess the effects of assisted reproductive technologies (ART) on indicators of epigenetic modifications, and the relationship between such epigenetic changes and infant neurodevelopmental, cardiovascular, and metabolic outcomes.

Study Type

OBSERVATIONAL

Enrollment

2,366

Conditions

Pregnancy Outcome

Eligibility

Sex: FEMALEMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Able to communicate in French or English Exclusion Criteria: * Current intravenous drug use * Severe illnesses or life threatening conditions * Multiple gestation pregnancies

Locations (1)

CHU Sainte-Justine

Montreal, Quebec, Canada

Outcomes

Primary Outcomes

Intrauterine growth restriction

Birth weight smaller than 10th percentile

Time frame: At delivery

Preterm birth

Delivery before 37 weeks of gestation

Time frame: At delivery

Neurodevelopment - Bayley

Neurodevelopmental assessment of the infant. Test used : Bayley Scales of Infant and Toddler Development (BSID-III; cognitive scale and motor scale combined). This test was done on 1520 children.