Profiling the Endocannabinoid Response to Hedonic Eating

N/ACompletedNCT03113474

Wageningen University25 enrolled

Overview

Study into the endocannabinoid response to consuming a palatable versus a neutral food.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

TRIPLE

Enrollment

Conditions

Obesity Food Preferences

Interventions

Food palatabilityOTHER

Food palatability is modulated

Eligibility

Sex: MALEMin age: 18 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy (self-report) * Dutch * Evaluating one of the used foods as palatable * Evaluating one of the used foods as neutral * Hb value between 8.1 and 11.0 mmol/L at screening Exclusion Criteria: * restraint eating * lack of appetite * difficulties eating/swallowing * endocrine disorders * energy restricted diet two months prior to study * weight change \> 5 kg in two months prior to study * stomach or bowel disease * taste or smell disorders (self-report) * not consuming foods used in the study * smoking \> 1 cigarette per day * drinking \> 21 units alcohol per week

Outcomes

Primary Outcomes

Endocannainoid levels

To assess changes in endocannabinoid plasma levels prior to, during and after eating a palatable versus a neutral food

Time frame: prior to, during and two hours after eating

Secondary Outcomes

Pancreatic polypeptide (pg/ml)

To assess changes in pancreatic polypeptide plasma levels prior to, during and after eating a palatable versus a neutral food

Time frame: prior to, during and two hours after eating

Ghrelin (pg/ml)

To assess changes in ghrelin plasma levels prior to, during and after eating a palatable versus a neutral food

Time frame: prior to, during and two hours after eating

Data from ClinicalTrials.gov

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