Fluid management being an important component of surgery becomes more challenging for an anesthesiologist in case of renal transplant. Ischemia-reperfusion injury is an inevitable consequence of kidney transplantation, leading to metabolic acidosis .Normal saline (NS; 0.9% NaCl) is administered during kidney transplantation to avoid the risk of hyperkalemia associated with potassium-containing fluids. Plasmalyte is another fluid which can be used and probably will lead to better metabolic profile in these group of patients.The primary objective of this study will be to compare the effects of using normal saline (NS), Ringer lactate and Plasmalyte as intravenous fluids on acid-base balance and electrolytes during living donor kidney transplantation. Secondary outcomes assessed will be the effect on renal function.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
TRIPLE
Enrollment
105
intravenous fluid to be used for maintainance and replacement during renal transplant surgery will be normal saline, ringer lactate or plasmalyte A depending on the arm of intervention
PGIMER
Chandigarh, India
RECRUITINGacid base balance, 4 readings intraoperaively to be taken using arterial blood sample of the patient
pH, pCO2, pO2, HCO3,Base deficit, Na, K are the values normally measured in acid base analysis
Time frame: during the surgery
serum creatinine on day 1, 2 and 7 of surgery
This is a function of kidney measure and will tell about the success of Renal Transplant
Time frame: day 1, 2 and 7
intraoperative hemodynamics in all patients
Time frame: intraoperatively
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