Contrast Enhanced Ultrasound of Carotid Plaque in Acute Ischemic Stroke

Versailles Hospital35 enrolled

Overview

This is a biomedical, single-center, and prospective study of a consecutive patients cohort in acute ischemic stroke with carotid plaque.

The main objective of this study is to evaluate the prevalence of the contrast taking carotid plaques in these acute ischemic strokes. The secondary objectives are: * to determine the clinical, sonographic, CT scanner and MRI characteristics of patients in constituted acute cerebral ischemia with carotid atherosclerotic plaque taking contrast to the doppler ultrasound. * to explore of the plaque contrast enhancement at 6 months (new injection).

Study Type

INTERVENTIONAL

Allocation

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Cerebral Infarction

Interventions

Contrast injection Sonovue®OTHER

In addition to standardized assessment routine care, a contrast injection will be performed during the neck vessels doppler ultrasound.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * All patients aged at least 18 years hospitalized with ischemic stroke signs in the carotid territory, objectified on brain MRI with positive DWI. * Carotid plaque \> 2.5 mm thickness in the ipsilateral carotid territory to the AIC, low echogenicity (Type 1, 2, 3, and 4a of the classification Geroulakos) measured by the assessment "GSM" (median gray level). * Free and informed consent patient or his representative for contrast injection microbubble. * Affiliated to health insurance. Exclusion Criteria: * Severe cerebral infarction with NIHSS\> 25 * No-indications to the contrast medium injection * Recent myocardial infarction, unstable angina. * Heart failure stage III / IV New York Heart Association. * Cardiac shunt left-right, respiratory distress. * Allergy to albumin or contrast agents. * Carotid plaques and hyperechoic calcified (however these plaques will be counted to determine their prevalence in acute AIC). * Carotid dissection

Locations (1)

Centre Hospitalier de Versailles

Le Chesnay, France

Outcomes

Primary Outcomes

Contrast enhancement of carotid plaque prevalence in ultrasound doppler

Time frame: Day 1

Secondary Outcomes

Patient's demographics data

Time frame: Day 1

Patient's sonographic and MRI characteristics.

confirmation of the recent character of stroke on the DWI, search for stroke sequelae and white matter disease on the FLAIR, search of the thrombus on the T2\*, search occluded artery on the 3DTOF

Time frame: Day1

describe the aspect of the carotid plaque on CT angiography.

NASCET stenosis and the aspect (smooth, irregular, ulcerated)

Time frame: between 1 to 5 days

Persistence , decrease or loss of contrast enhancement in ultrasound doppler.

Time frame: Month 6

Cerebral infarction recurrence

Time frame: Month 6

Data from ClinicalTrials.gov

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