Millions of older adults are hospitalized for a critical illness each year and although they are more likely than ever to survive this illness, they commonly face significant morbidity in the form of disabilities in basic self-care activities and in mobility in the months and years afterwards. A better understanding of the underlying risk factors for disability following critical illness is greatly needed, including the effect that activity during hospitalization may have on these outcomes. Therefore, we designed the Measuring OutcomeS of Activity in Intensive Care (MOSAIC) observational study to evaluate the relationship between activity (measured more rigorously than in prior investigations) and disability, physical function, and cognitive function in survivors of critical illness 3 and 12 months after ICU discharge.
The MOSAIC observational study will measure activity in critically ill patients for up to 28 days in the hospital using two different, objective measures, a clinical mobility scale and accelerometry. We will evaluate the independent association between activity and outcomes 3 and 12 months after ICU discharge. Specifically, Aim 1 will determine the relationship between activity and disability in ADLs and mobility. Aim 2a will determine the relationship between activity and physical and cognitive function. Aim 2b will evaluate physical and cognitive function as mediators of long-term disability. Aim 3a will determine the relationship between activity and biomarkers of inflammation and coagulation. Aim 3b will determine the relationship between these biomarkers of inflammation and coagulation and disability, physical and cognitive function.
Study Type
OBSERVATIONAL
Enrollment
312
The Ohio State University Medical Center
Columbus, Ohio, United States
Vanderbilt University Medical Center
Nashville, Tennessee, United States
Precipitating Events Project Disability Questionnaire
Questionnaire assessment of activities of daily living and mobility
Time frame: 12 months
Life Space Assessment Questionnaire
Questionnaire assessment of activities of community mobility
Time frame: 12 months
Precipitating Events Project Disability Questionnaire
Questionnaire assessment of activities of daily living and mobility
Time frame: 3 months
Life Space Assessment Questionnaire
Questionnaire assessment of activities of community mobility
Time frame: 3 months
Survival
Proportion of patients surviving at 30, 90, and 365 days
Time frame: 30, 90, and 365 days
Ventilator-free days
Days alive and free of mechanical ventilation
Time frame: out of 28 days
Delirium and coma-free days
Days alive and without delirium or coma
Time frame: out of 28 days
ICU Length of Stay
Days spent in the ICU during the index hospitalization
Time frame: up to 28 days
Hospital Length of Stay
Days spent in the hospital during the index hospitalization
Time frame: up to 28 days
Short Physical Performance Battery
Performance Measure of Physical Function
Time frame: 3 months
Short Physical Performance Battery
Performance Measure of Physical Function
Time frame: 12 months
Handgrip Dynamometry
Performance Measure of Muscle Strength
Time frame: 3 months
Handgrip Dynamometry
Performance Measure of Muscle Strength
Time frame: 12 months
Repeatable Battery for the Assessment of Neuropsychological Status
Test of Global Cognition
Time frame: 3 months
Repeatable Battery for the Assessment of Neuropsychological Status
Test of Global Cognition
Time frame: 12 months
Trail Making Test Parts A & B
Test of Executive Function
Time frame: 3 months
Trail Making Test Parts A & B
Test of Executive Function
Time frame: 12 months
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