Validate the use of fetal urine peptidome-analysis and explore amniotic fluid markers for the stratification of fetuses with Posterior Urethral Valve for post-natal renal function.
The ANTENATAL project requires the use of fetal urine as well as post-natal urine, post-natal serum and, possibly, amniotic liquid. We will take an additional tube during the takings collected for routine management of the disease. The analysis of samples will be carried out in Toulouse at the Institute of Metabolic and Cardiovascular Diseases or with fee-for-service suppliers.
Study Type
OBSERVATIONAL
Enrollment
400
Renal/patient survival at 2 years post-natally.
Defined by the need for dialysis or death.
Time frame: Year 2
Renal function of the survivors at day 4 and 6 and 12 month post-natally.
This post-natal renal function, estimated via serum cystatin C concentrations, will be analysed centrally in Toulouse to homogenise the analysis.
Time frame: Year 1
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