This prospective study enrolls patients who are diagnosed with aggressive lymphoma including Hodgkin and non-Hodgkin lymphomas. Enrolled patients will be treated according to our institution' treatment policy in clinical practice. The disease status including response to therapy and survival status will be regularly updated during the study period. Patients' serum and cell-free DNA will be collected and analyzed.
The study population is aggressive lymphomas requiring systemic chemotherapy. Newly diagnosed or relapsed/refractory patients can be enrolled into the study. Patients can be treated according to the principle of routine care of our institute. The study process is as follows. 1. Registration after informed consent. 2. Laboratory and radiological evaluation after registration including collection of serum and cell-free DNA from patients' peripheral blood 3. Interim and final response evaluation including collection of serum and cell-free DNA from patients' peripheral blood 4. Regular monitoring disease status and update of survival status 5. Laboratory and radiological evaluation after relapse or progression including collection of serum and cell-free DNA from patients' peripheral blood
Study Type
OBSERVATIONAL
Enrollment
600
Systemic chemotherapy with curative intent
Samsung Medical Center
Seoul, South Korea
RECRUITINGResponse rate
response to chemotherapy
Time frame: 3 months after chemotherapy
Progression-free survival
Time to relapse/progression or any kinds of death
Time frame: 3 year
Overall survival
Time to any kinds of death
Time frame: 3 year
Biomarker
Development of biomarker predicting response and survival outcome
Time frame: 3 year
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