Patients will be randomized to Gradual or immediate Goal-dose EN group at day 3 after abdominal surgery. Patients will receive Goal-dose EN gradually or immediately after abdominal surgery. Both groups will receive EN for 5 days except 80% of target energy delivered by oral feeding or patients are discharged from hospital. The primary and secondary outcomes will be collected.
Patients after abdominal surgery will receive enteral nutrition for 2 days, if she/he can tolerate 30% of goal-dose EN, then she/he will be randomized to Gradual or immediate Goal-dose EN group at day 3. Patients in Gradual Goal-dose EN group will receive increased calories gradually by EN and will reach the 80% of target energy by EN at day 8 while patients in immediate Goal-dose EN group will receive 100% of target energy by EN at day 3 after abdominal surgery. Both groups will receive EN for 5 days except 80% of target energy delivered by oral feeding or patients are discharged from hospital, whichever arrives first. The primary and secondary outcomes will be collected.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
411
Patients in Gradual Goal-dose EN group will receive increased calories gradually by EN and will reach the 80% of target energy by EN at day 8 while patients in immediate Goal-dose EN group will receive 100% of target energy by EN at day 3 after abdominal surgery. Both of the two group will receive EN for 5 days except 80% of target energy delivered by oral feeding or patients are discharged from hospital, whichever arrives first.
Jinling Hospital, China
Nanjing, Jiangsu, China
Morbidity of infection
Invasion of the host organism by microorganisms that can cause pathological conditions or diseases.
Time frame: From date of randomization until the date of infection from any cause, assessed up to 2 months.
Actual calories intake
The total energy patients received during the intervention.
Time frame: During the intervention, assessed up to 2 months.
Scale the frequency of gastrointestinal intolerance
Diarrhea, vomiting, abdominal distention or cramping and abdominal pain.
Time frame: During the intervention, assessed up to 2 months.
Laboratory examination
Albumin, pre-albumin, transferrin and retinol conjugated protein
Time frame: At the date of patients enrollment and after intervention, assessed up to 2 months.
Length of stay in hospital
The length of patients stay in hospital
Time frame: From date of operation until the date of patients discharged from hospital, assessed up to 12 months.
Mortality
All deaths reported in all enrolled patients.
Time frame: From date of randomization until the date of death, assessed up to 2 months after patients discharged from hospital.
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