Beta-Glucan Driven vs. Empirical Antifungal Therapy in Critically Ill Patients

Inclusion Criteria: * ICU admission (minimum of 48 hours in ICU with an expected length of stay of at least 48 hours) * Ongoing Mechanical Ventilation * Presence of CVC * Sepsis/Septic Shock development while receiving broad spectrum antibiotics * Positivity of Candida Score or Candida Colonization Index in absence of septic shock Exclusion Criteria: * Complicated Candida Infection * Already ongoing anti fungal therapy * Beta Glucan test not available * Absence of informed consent * Immunesuppressive status (long-term immunesuppresive or steroids therapy; AIDS; WBC \<1000/mmc or neutrophils \<500/mmc) * Pregnancy * Already enrolled in other interventional studies