Brain and Mindfulness

Hospices Civils de Lyon169 enrolled

Overview

The main aim of this project is to explore the neuro-anatomical and -physiological correlates of meditation on attention and emotion-regulation. By investigating this, our scientific goal is to more generally identify the mechanisms and biomarkers of health and mental well-being. Therefore, the investigators use non-invasive imaging like Magneto-EncephaloGraphy (MEG), ElectroEncephaloGraphy (EEG), functional and anatomic Magnetic Resonance Imaging (MRI; including Diffusion tensor - DTI). These brain measures will then be linked to behavioral measurements. Experimental methods (i.e., simple computer tasks) will be used to measure attention, conscious perception and regulation of pain and emotion.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

169

Conditions

Healthy

Interventions

Magneto-encephalography (MEG)OTHER

Magneto-encephalography

Electro-encephalography (EEG)OTHER

Electro-encephalography

Functional Magnetic Resonance Imaging (fMRI)OTHER

Functional Magnetic Resonance Imaging

Eligibility

Sex: ALLMin age: 25 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age : 25-70 * Being affiliated to a social security system. * Motivated to participate in this study. Exclusion Criteria: * Medication acting on the central nervous system * Opioids, Antidepressive Agents. * Actual or previous neurological or psychiatric illnesses * Chronic pain or any other medical condition which is related to pain or an increased sensitivity to pain. * Not having a personal or family history of epilepsy * Alcohol or drugs consumption 2 days before or during the study.

Locations (1)

Le Vinatier

Bron, France

Outcomes

Primary Outcomes

Anatomical MRI scan

Brain structure

Time frame: Day 1

Functional MRI scan

Brain activation: Haemodynamic response - BOLD signal.

Time frame: Day1

EEG

Event-related potential fields : amplitude in fT and latency in ms. Oscillations : power spectral density and time-frequency oscillations in fT\^2/Hz

Time frame: Day 1

Secondary Outcomes

Behavioral measure : Accuracy of the performed task actions

Participants will perform behavioral computer tasks in which accuracy and speed is important. Performance behavior will be measured in this task: Accuracy of the performed task actions: number of errors and hits

Time frame: Day 1

Psychophysics: Pain threshold

Pain threshold: The threshold of pain or pain threshold is the point along a curve of increasing perception of a stimulus at which pain begins to be felt. The temperature in degrees Celcius at which heat becomes painful for a recipient.

Time frame: Day 1

Psychophysiology : Respiration

Respiration rate: breaths/minute

Time frame: Day 1

Subjective experience of the participant

Time frame: Day 1

Studies biomarkers of inflammation

area of the inflamed site in mm\^2, obtained by automatic image processing of a photography

Data from ClinicalTrials.gov

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