Effects of Retinoids on CYP2D6 Activity During Pregnancy

University of Washington82 enrolled

Overview

Prospective drug interaction study during pregnancy.

A randomized pharmacokinetic study to evaluate CYP2D6 activity with and without vitamin A administration during pregnancy and compared to postpartum control.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

CYP2D6 Polymorphism

Interventions

Vitamin ADRUG

vitamin A daily X3-4 weeks

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Singleton pregnancies * Extensive metabolizers Exclusion Criteria: * Chronic or persistent cough accompanying asthma, smoking or chronic obstructive pulmonary disease * Productive cough * Fever * Known kidney disease * Known liver disease * Diabetes * Obesity * Bipolar disease * Attention deficit disorder * Social phobia * Allergy or history of adverse event with dextromethorphan * Drugs, foods, beverages or dietary supplements that interact with CYP2D6 or dextromethorphan * dextromethorphan * Unable to give written informed consent * Inability to fast * Concurrent use of vitamin A supplementation

Locations (1)

University of Washington

Seattle, Washington, United States

Outcomes

Primary Outcomes

CYP2D6 activity: dextromethorphan metabolic ratio

dextromethorphan metabolic ratio change from baseline during pregnancy

Time frame: 4 weeks

Data from ClinicalTrials.gov

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