Poor sleep quality may lead to increase in oxidative stress and free radicals which in turn may decrease the reproductive function. Many researchers have already proven improvement on reproductive function after antioxidant (melatonin) administration. The investigators wish to study the relationship between unexplained, young poor ovarian responder and oxidative stress.
Poor sleep quality may lead to increase in oxidative stress and free radicals which in turn may decrease the reproductive function. Many researchers have already proven improvement on reproductive function after antioxidant (melatonin) administration. The investigators wish to study the relationship between unexplained, young poor ovarian responder and oxidative stress. This is an randomized controlled trial to evaluate the effect of melatonin to improve the quality of sleep and reduce the oxidative stress. 100 patients will be randomized in to two groups, the one with melatonin administration for 2 weeks and the other with placebo administration. Each group will be composed of 2 sub groups, poor responders and normal responders. Then the serum and the follicular fluid will be collected at the time of oocyte retrieval and melatonin concentration oxidative stress marker will be measured.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
DOUBLE
Enrollment
100
The drug, melatonin will be taken every night from the time of COH to the date of oocyte retrieval. The method of administration is as follows: Melatonin 2mg once a day, 1 to 2 hours before bedtime for about 2 weeks until the date of oocyte retrieval.
the drug, placebo pill will be taken every night from the time of COH to the date of oocyte retrieval. The method of administration is as follows: placebo pill once a day, 1 to 2 hours before bedtime for about 2 weeks until the date of oocyte retrieval.
Bundang CHA medical center
Seongnam-si, Gyeonggi-do, South Korea
IVF outcome - oocyte quality
Evaluate oocyte quality on morphological standard as following category- Mature oocyte, Intermediate oocyte, atretic oocyte, post mature oocyte
Time frame: 3 days after oocyte retrieval
IVF outcome - embryo quality
grade the embryos\& blastocysts according to the Lucinda Veeck \& Gardner
Time frame: 3 to 5 days after oocyte retrieval
IVF outcome -biochemical pregnancy rate
serum human chorionic gonadotropin level\>10 IU
Time frame: on day 12~14 after embryo transfer
IVF outcome - clinical pregnancy rate
presence of G-sac in the uterine cavity
Time frame: at 6-8 weeks of gestation
acquired oocyte No
number
Time frame: 20weeks
fertilization rate
ratio of no. of fertilized egg/ no of total retrieved eggs
Time frame: 20weeks
Comparing Pittsburgh sleep quality index
questionaires to evaluate the participants quality of the sleep. cut off : 13 points This questionaire is to be asked to the participants twice, before and after the administration of the drug
Time frame: 20weeks
marker(melatonin level, receptor, 8-OHdg) in serum, follicular fluid and endometrium during IVF
:pg/ml units are used
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Time frame: 20weeks