The aim of this study is to evaluate modulation of anti-tumor T cell responses in cancer patients treated by concomitant radiochemotherapy (i-RTCT)
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
220
blood and tumor tissue sample
CHU de Besançon
Besançon, France
RECRUITINGCentre Georges François LECLERC
Dijon, France
RECRUITINGHôpital Nord Franche-Comté
Montbéliard, France
RECRUITINGtumor antigen specific T-cell responses
tumor antigen specific T-cell responses
Time frame: up to 12 months after the end of radiochemotherapy
monitoring of immune checkpoints, immune cell death, immune suppressive cells and T-cell polarisation
monitoring of immune checkpoints, immune cell death, immune suppressive cells and T-cell polarisation
Time frame: up to 12 months after the end of radiochemotherapy
Progression free survival
time interval between the date of initiation of treatment and the date of first progression (local, remote \[extent of the disease by RECIST v1.1\] second cancer) or death from any cause
Time frame: date of first progression of the disease (within 2 year after the initiation of the treatment)]
overall survival
time between the date of initiation of treatment and the date of death from any cause
Time frame: date of death from any cause (within 2 years after the initiation of the treatment)
Quality of life related to health measured by EORTC-QLQC30
Quality of life related to health measured by EORTC-QLQC30
Time frame: from the inclusion to patient death, up to 1 year
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Institut Jean Godinot
Reims, France
RECRUITING