Treatment of NAFLD With Two Different Diets

Karolinska University Hospital74 enrolled

Overview

The impact of popular diets on liver-related health is unclear. In this randomized, controlled trial, patients with NAFLD will be randomized to one of two popular diets or a placebo diet.

Subjects will include patients with MRI-verified NAFLD, with no concurrent liver diseases. Randomization will be done to either a control diet, the 5:2 diet or a low-carb-high-fat diet. The subjects will follow the diet for three months, after which a new MRI is performed. Main outcomes measure is reduction in liver fat.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

NAFLD

Interventions

5:2 dietBEHAVIORAL

Dietary intervention according to 5:2 diet during three months.

LCHFBEHAVIORAL

Dietary intervention according to LCHF diet during three months.

Placebo dietBEHAVIORAL

Placebo diet: normal dietary advice

Eligibility

Sex: ALLHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Known NAFLD Exclusion Criteria: * Other forms of liver disease * Bolus insulin treatment * Cirrhosis

Locations (1)

Center for Digestive Diseases, Karolinska University Hospital

Stockholm, Sweden

Outcomes

Primary Outcomes

Liver fat

MRI-measured liver fat content

Time frame: Three months

Data from ClinicalTrials.gov

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