The goal of the Fontan Imaging Biomarkers (FIB) study is to identify the associations of blood and urine biomarkers to imaging parameters of ventricular mechanics.
This study has the following research questions: 1. What is the reproducibility of ventricular systolic function measurements (including ventricular strain) in Fontan patients using echocardiography (Echo) and cardiac magnetic resonance imaging (CMR)? 2. What is the reproducibility of ventricular diastolic function measurements (including tissue Doppler and strain rate) in Fontan patients using Echo and CMR? 3. Is there a correlation between ventricular function measurements and circulating biomarkers (including galectin-3 levels, NT-proBNP, ST2, and MELD-XI score)?
Study Type
OBSERVATIONAL
Enrollment
200
Boston Children's Hospital
Boston, Massachusetts, United States
Biomarkers
Correlation of biomarkers and imaging parameters of ventricular mechanics
Time frame: Through study completion, an average of 3 years
Diastolic function
Reproducibility of parameters of systolic function
Time frame: Through study completion, an average of 3 years
Systolic function
Reproducibility of parameters of systolic function
Time frame: Through study completion, an average of 3 years
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