The investigators aim to evaluate the feasibility of a resistance exercise training program among individuals with CKD and its impact on endothelial and vascular function.
Resistance exercise training has been shown to improve cardiovascular health including endothelial function in general populations, but studies in patients with chronic kidney disease (CKD) are limited. The investigators aim to evaluate the feasibility and acceptability of a resistance exercise training program among individuals with CKD and its impact on endothelial and vascular function as measured by brachial artery flow-mediated dilation, pulse-wave velocity and carotid artery stiffness. To accomplish this goal the investigators propose to conduct a 12-week pilot randomized controlled trial of twice a week resistance exercise training among 32 adults with CKD. The results of this study will inform the design and implementation of a larger trial evaluating the impact of resistance exercise training on adverse outcomes in patients with CKD including CKD progression.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
34
12-week resistance exercise training program, 2 times per week, 45 min per session. Eight exercises will be used to include large upper and lower body muscle groups (leg press, leg extension, leg curl, chest press, shoulder extension, biceps curl, abdominal crunch and back extension). The baseline one repetition maximum will be used to set initial training loads.
University of Illinois at Chicago
Chicago, Illinois, United States
Endothelial function
Measured by brachial artery flow-mediated dilation (FMD)
Time frame: 3 months
Vascular function
Measured by pulse wave velocity
Time frame: 3 months
Carotid artery stiffness
Measured by non-invasive ultrasound
Time frame: 3 months
Self-reported physical activity
Assessed by the MESA (Multiethnic Study of Atherosclerosis) Typical Week Physical Activity Survey
Time frame: 3 months
Objectively measured physical activity
Assessed by a physical activity monitor (ActiGraph GT3X+)
Time frame: 3 months
Systolic blood pressure
Measured using standard procedures
Time frame: 3 months
Serum LDL-cholesterol
Measured using standard procedures
Time frame: 3 months
Serum HDL-cholesterol
Measured using standard procedures
Time frame: 3 months
Muscle strength
Assessed by the amount of weight lifted in a single chest press and leg press (1 RM).
Time frame: 3 months
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